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JARID2 Antikörper (AA 1-159)

Dieses Anti-JARID2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von JARID2 in ELISA, IF und IHC. Geeignet für Human.
Produktnummer ABIN7165672

Kurzübersicht für JARID2 Antikörper (AA 1-159) (ABIN7165672)

Target

Alle JARID2 Antikörper anzeigen
JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Reaktivität

  • 42
  • 16
  • 9
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 33
  • 9
  • 2
  • 1
Kaninchen

Klonalität

  • 34
  • 11
Polyklonal

Konjugat

  • 20
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser JARID2 Antikörper ist unkonjugiert

Applikation

  • 31
  • 13
  • 13
  • 11
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-159

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Protein Jumonji protein (1-159AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

    Andere Bezeichnung

    JARID2

    Hintergrund

    Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of \\\'Lys-27\\\' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of \\\'Lys-9\\\' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

    Aliases: JARD2 antibody, JARD2_HUMAN antibody, JARID2 antibody, JMJ antibody, Jumonji AT rich interactive domain 2 antibody, Jumonji homolog antibody, Jumonji like protein antibody, Jumonji protein antibody, Jumonji/ARID domain containing protein 2 antibody, Jumonji/ARID domain-containing protein 2 antibody, Protein Jumonji antibody

    UniProt

    Q92833

    Pathways

    Chromatin Binding
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