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ECT2 Antikörper (AA 283-453)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ECT2 in WB, ELISA, IHC und IP. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7165313

Kurzübersicht für ECT2 Antikörper (AA 283-453) (ABIN7165313)

Target

Alle ECT2 Antikörper anzeigen
ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

Reaktivität

  • 63
  • 12
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 58
  • 4
  • 1
Kaninchen

Klonalität

  • 59
  • 4
Polyklonal

Konjugat

  • 28
  • 8
  • 5
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ECT2 Antikörper ist unkonjugiert

Applikation

  • 48
  • 20
  • 20
  • 14
  • 14
  • 8
  • 8
  • 7
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • Bindungsspezifität

    • 15
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 283-453

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Protein ECT2 protein (283-453AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IP:1:200-1:2000,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

    Andere Bezeichnung

    ECT2

    Hintergrund

    Background: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

    Aliases: ECT2Protein ECT2 antibody, Epithelial cell-transforming sequence 2 oncogene antibody

    UniProt

    Q9H8V3

    Pathways

    Neurotrophin Signalübertragung, Cell-Cell Junction Organization
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