PRMT6 Antikörper (AA 119-375) (FITC)

Produktnummer ABIN7165079

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRMT6 in . Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PRMT6 Antikörper (AA 119-375) (FITC) (ABIN7165079)

Target: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT6 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-PRMT6 Antikörper (FITC)

Bindungsspezifität: AA 119-375

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Protein arginine N-methyltransferase 6 protein (119-375AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRMT6

Target: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Andere Bezeichnung: PRMT6

Hintergrund:

Background: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 \\\'Arg-2\\\' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 \\\'Lys-4\\\' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 \\\'Arg-3\\\' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

Aliases: ANM6_HUMAN antibody, Chromobox protein homolog 7 antibody, FLJ10559 antibody, FLJ51477 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 antibody, Histone-arginine N-methyltransferase PRMT6 antibody, HMT1 hnRNP methyltransferase like 6. antibody, HRMT1L6 antibody, OTTHUMP00000012633 antibody, PRMT 6 antibody, prmt6 antibody, Protein arginine methyltransferase 6 antibody, Protein arginine N methyltransferase 6 antibody, Protein arginine N-methyltransferase 6 antibody

UniProt: Q96LA8