PSTPIP1 Antikörper (AA 157-416)

Produktnummer ABIN7164772

Dieses Anti-PSTPIP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PSTPIP1 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für PSTPIP1 Antikörper (AA 157-416) (ABIN7164772)

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSTPIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-PSTPIP1 Antikörper

Bindungsspezifität: AA 157-416

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PSTPIP1

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Andere Bezeichnung: PSTPIP1

Hintergrund:

Background: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Aliases: CD2 antigen binding protein 1 antibody, CD2 binding protein 1 antibody, CD2 cytoplasmic tail binding protein antibody, CD2-binding protein 1 antibody, CD2BP1 antibody, CD2BP1L antibody, CD2BP1S antibody, H PIP antibody, H-PIP antibody, HPIP antibody, PAPAS antibody, PEST phosphatase interacting protein 1 antibody, PEST phosphatase-interacting protein 1 antibody, PPIP1_HUMAN antibody, Proline serine threonine phosphatase interacting protein 1 antibody, Proline-serine-threonine phosphatase-interacting protein 1 antibody, PSTPIP antibody, Pstpip1 antibody

UniProt: O43586