PBX1 Antikörper (AA 315-430) (FITC)

Produktnummer ABIN7164139

Dieses Anti-PBX1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PBX1 in . Geeignet für Human.

Kurzübersicht für PBX1 Antikörper (AA 315-430) (FITC) (ABIN7164139)

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PBX1 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-PBX1 Antikörper (FITC)

Bindungsspezifität: AA 315-430

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Pre-B-cell leukemia transcription factor 1 protein (315-430AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PBX1

Target: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Andere Bezeichnung: PBX1

Hintergrund:

Background: Binds the sequence 5\'-ATCAATCAA-3\'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1,19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).

Aliases: DKFZp686B09108 antibody, Homeo box protein PBX1 antibody, Homeo box protein PRL antibody, Homeobox protein PBX 1 antibody, Homeobox protein PBX1 antibody, Homeobox protein PRL antibody, MGC126627 antibody, PBX 1 antibody, Pbx1 antibody, PBX1_HUMAN antibody, Pre B cell leukemia homeobox 1 antibody, Pre B cell leukemia transcription factor 1 antibody, Pre-B-cell leukemia transcription factor 1 antibody, PRL antibody

UniProt: P40424