PQBP1 Antikörper (AA 2-265)

Produktnummer ABIN7163840

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PQBP1 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PQBP1 Antikörper (AA 2-265) (ABIN7163840)

Target: PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PQBP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-PQBP1 Antikörper

Bindungsspezifität: AA 2-265

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Polyglutamine-binding protein 1 protein (2-265AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PQBP1

Target: PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))

Andere Bezeichnung: PQBP1

Hintergrund:

Background: Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.

Aliases: 38 kDa nuclear protein containing a WW domain antibody, Mental retardation, X linked 55 antibody, MRX55 antibody, MRXS3 antibody, MRXS8 antibody, Npw38 antibody, Nuclear protein containing WW domain 38 kD antibody, OTTHUMP00000025808 antibody, Polyglutamine binding protein 1 antibody, Polyglutamine tract binding protein 1 antibody, Polyglutamine tract-binding protein 1 antibody, Polyglutamine-binding protein 1 antibody, PQBP 1 antibody, PQBP-1 antibody, PQBP1 antibody, PQBP1_HUMAN antibody, RENS1 antibody, SHS antibody, Sutherland Haan X linked mental retardation syndrome antibody

UniProt: O60828

Pathways: Ribonucleoprotein Complex Subunit Organization