PCGF2 Antikörper (AA 103-316)

Produktnummer ABIN7163798

Produktdetails anti-PCGF2 Antikörper

Target: PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))

Bindungsspezifität: AA 103-316

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCGF2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Polycomb group RING finger protein 2 protein (103-316AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PCGF2

Target: PCGF2 (Polycomb Group Ring Finger 2 (PCGF2))

Andere Bezeichnung: PCGF2 (PCGF2 Produkte)

Synonyme: ZNF144 antikoerper, PCGF2 antikoerper, MEL-18 antikoerper, RNF110 antikoerper, Mel18 antikoerper, Rnf110 antikoerper, Zfp144 antikoerper, mel-18 antikoerper, polycomb group ring finger 2 antikoerper, PCGF2 antikoerper, Pcgf2 antikoerper

Hintergrund:

Background: Transcriptional repressor. Binds specifically to the DNA sequence 5\'-GACTNGACT-3\'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A \'Lys-119\', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1, unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

Aliases: DNA binding protein Mel 18 antibody, DNA-binding protein Mel-18 antibody, Mel 18 antibody, MGC10545 antibody, PCGF 2 antibody, PCGF2 antibody, PCGF2_HUMAN antibody, Polycomb group ring finger 2 antibody, Polycomb group RING finger protein 2 antibody, RING finger protein 110 antibody, RNF110 antibody, Zinc finger protein 144 antibody, ZNF 144 antibody, ZNF144 antibody

UniProt: P35227

Pathways: Chromatin Binding