PARG Antikörper (AA 1-348) (FITC)
Kurzübersicht für PARG Antikörper (AA 1-348) (FITC) (ABIN7163767)
Target
Alle PARG Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1-348
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Kreuzreaktivität
- Human
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)
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Isotyp
- IgG
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anti-PARG (PARG) (AA 1-976) antibody
PARG Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-PARG (PARG) (AA 390-421), (C-Term) antibodyPARG Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB14201-RB14549 unconjugated
anti-PARG (PARG) (AA 1-348) antibodyPARG Reaktivität: Human ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-PARG (PARG) (AA 777-976) antibodyPARG Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-PARG (PARG) (AA 770-819) antibodyPARG Reaktivität: Human, Meerschweinchen, Pferd, Affe WB Wirt: Kaninchen Polyclonal unconjugated
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PARG
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Andere Bezeichnung
- PARG
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Hintergrund
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Background: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Aliases: ADP riboseglycohydrolase antibody, Mitochondrial poly(ADP ribose) glycohydrolase antibody, Parg antibody, PARG_HUMAN antibody, PARG99 antibody, Poly antibody, poly (ADP ribose) glycohydrolase antibody, poly(ADP-ribose) glycohydrolase 60 kDa isoform antibody, Poly(ADP-ribose) glycohydrolase antibody
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UniProt
- Q86W56
Target
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