PIWIL1 Antikörper (AA 390-690)

Produktnummer ABIN7163477

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PIWIL1 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PIWIL1 Antikörper (AA 390-690) (ABIN7163477)

Target: PIWIL1 (Piwi-Like 1 (PIWIL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIWIL1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-PIWIL1 Antikörper

Bindungsspezifität: AA 390-690

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Piwi-like protein 1 protein (390-690AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIWIL1

Target: PIWIL1 (Piwi-Like 1 (PIWIL1))

Andere Bezeichnung: PIWIL1

Hintergrund:

Background: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator (PubMed:12037681, PubMed:16287078).

Aliases: HIWI antibody, MIWI antibody, Piwi (Drosophila) like 1 antibody, PIWI antibody, Piwi homolog antibody, Piwi like 1 (drosophila) antibody, Piwi like 1 antibody, Piwi-like protein 1 antibody, PIWIL1 antibody, PIWL1_HUMAN antibody

UniProt: Q96J94