PITX3 Antikörper (AA 10-200) (HRP)

Produktnummer ABIN7163472

Der Kaninchen Polyklonal Anti-PITX3-Antikörper wurde für ELISA validiert. Er ist geeignet, PITX3 in Proben von Human zu detektieren.

Kurzübersicht für PITX3 Antikörper (AA 10-200) (HRP) (ABIN7163472)

Target: PITX3 (Pituitary Homeobox 3 (PITX3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PITX3 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-PITX3 Antikörper (HRP)

Bindungsspezifität: AA 10-200

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Pituitary homeobox 3 protein (10-200AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PITX3

Target: PITX3 (Pituitary Homeobox 3 (PITX3))

Andere Bezeichnung: PITX3

Hintergrund:

Background: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

Aliases: Homeobox protein PITX 3 antibody, Homeobox protein PITX3 antibody, MGC12766 antibody, Paired like homeodomain transcription factor 3 antibody, Paired-like homeodomain transcription factor 3 antibody, Pituitary homeobox 3 antibody, PITX 3 antibody, Pitx3 antibody, PITX3_HUMAN antibody, PTX 3 antibody, PTX3 antibody

UniProt: O75364