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PITX3 Antikörper (AA 10-200) (HRP)

Der Kaninchen Polyklonal Anti-PITX3-Antikörper wurde für ELISA validiert. Er ist geeignet, PITX3 in Proben von Human zu detektieren.
Produktnummer ABIN7163472

Kurzübersicht für PITX3 Antikörper (AA 10-200) (HRP) (ABIN7163472)

Target

Alle PITX3 Antikörper anzeigen
PITX3 (Pituitary Homeobox 3 (PITX3))

Reaktivität

  • 26
  • 26
  • 22
  • 19
  • 5
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 1
Human

Wirt

  • 41
  • 1
Kaninchen

Klonalität

  • 38
  • 4
Polyklonal

Konjugat

  • 19
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PITX3 Antikörper ist konjugiert mit HRP

Applikation

  • 29
  • 13
  • 13
  • 13
  • 9
  • 5
  • 4
  • 3
  • 3
  • 1
ELISA
  • Bindungsspezifität

    • 15
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 10-200

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Pituitary homeobox 3 protein (10-200AA)

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    PITX3 (Pituitary Homeobox 3 (PITX3))

    Andere Bezeichnung

    PITX3

    Hintergrund

    Background: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

    Aliases: Homeobox protein PITX 3 antibody, Homeobox protein PITX3 antibody, MGC12766 antibody, Paired like homeodomain transcription factor 3 antibody, Paired-like homeodomain transcription factor 3 antibody, Pituitary homeobox 3 antibody, PITX 3 antibody, Pitx3 antibody, PITX3_HUMAN antibody, PTX 3 antibody, PTX3 antibody

    UniProt

    O75364
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