PCID2 Antikörper (AA 2-250)

Produktnummer ABIN7162710

Der Kaninchen Polyklonal Anti-PCID2-Antikörper wurde für ELISA, IHC und IF validiert. Er ist geeignet, PCID2 in Proben von Human zu detektieren.

Kurzübersicht für PCID2 Antikörper (AA 2-250) (ABIN7162710)

Target: PCID2 (PCI Domain Containing 2 (PCID2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCID2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PCID2 Antikörper

Bindungsspezifität: AA 2-250

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human PCI domain-containing protein 2 protein (2-250AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PCID2

Target: PCID2 (PCI Domain Containing 2 (PCID2))

Andere Bezeichnung: PCID2

Hintergrund:

Background: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

Aliases: CSN12 like protein antibody, CSN12-like protein antibody, DKFZp686C20226 antibody, F10 antibody, FLJ11305 antibody, FLJ99362 antibody, HT004 antibody, MGC16774 antibody, PCI domain containing 2 antibody, PCI domain containing protein 2 antibody, PCI domain-containing protein 2 antibody, PCID2 antibody, PCID2_HUMAN antibody, RP11 - 98F14.6 antibody

UniProt: Q5JVF3