OSBP Antikörper (AA 628-802)

Produktnummer ABIN7162395

Der Kaninchen Polyklonal Anti-OSBP-Antikörper wurde für ELISA und IF validiert. Er ist geeignet, OSBP in Proben von Human zu detektieren.

Kurzübersicht für OSBP Antikörper (AA 628-802) (ABIN7162395)

Target: OSBP (Oxysterol Binding Protein (OSBP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OSBP Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-OSBP Antikörper

Bindungsspezifität: AA 628-802

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Oxysterol-binding protein 1 protein (628-802AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu OSBP

Target: OSBP (Oxysterol Binding Protein (OSBP))

Andere Bezeichnung: OSBP

Hintergrund:

Background: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).

Aliases: OSBP 1 antibody, OSBP antibody, OSBP1_HUMAN antibody, Oxysterol binding protein 1 antibody, Oxysterol-binding protein 1 antibody

UniProt: P22059