NME4 Antikörper (AA 1-187)

Produktnummer ABIN7162056

Der Kaninchen Polyklonal Anti-NME4-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, NME4 in Proben von Human zu detektieren.

Kurzübersicht für NME4 Antikörper (AA 1-187) (ABIN7162056)

Target: NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NME4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-NME4 Antikörper

Bindungsspezifität: AA 1-187

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Nucleoside diphosphate kinase, mitochondrial protein (1-187AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NME4

Target: NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))

Andere Bezeichnung: NME4

Hintergrund:

Background: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin, the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK, its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).

Aliases: metastatic inhibition factor NM23H4 antibody, mitochondrial antibody, NDK antibody, NDKM_HUMAN antibody, NDP kinase antibody, NDP kinase D antibody, NDP kinase, mitochondrial antibody, NDPK D antibody, NDPKD antibody, nm23 H4 antibody, nm23-H4 antibody, NM23D antibody, NM23H4 antibody, Nm23M4 antibody, NME/NM23 nucleoside diphosphate kinase 4 antibody, NME4 antibody, Non metastatic cells 4 protein expressed in antibody, Non metastatic protein 23, homolog 4 antibody, Nucleoside diphosphate kinase D antibody, Nucleoside diphosphate kinase, mitochondrial antibody, Nucleoside diphosphate kinase, mitochondrial antibody

UniProt: O00746

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process