Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

NUPR1 Antikörper (AA 2-64)

NUPR1 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7161848
  • Target Alle NUPR1 Antikörper anzeigen
    NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))
    Bindungsspezifität
    • 15
    • 4
    • 2
    • 1
    • 1
    AA 2-64
    Reaktivität
    • 23
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 21
    • 2
    • 1
    Kaninchen
    Klonalität
    • 22
    • 1
    Polyklonal
    Konjugat
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NUPR1 Antikörper ist unkonjugiert
    Applikation
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Nuclear protein 1 protein (2-64AA)
    Isotyp
    IgG
  • Applikationshinweise
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))
    Andere Bezeichnung
    NUPR1 (NUPR1 Produkte)
    Synonyme
    COM1 antikoerper, P8 antikoerper, 2310032H04Rik antikoerper, Com1 antikoerper, p8 antikoerper, nuclear protein 1, transcriptional regulator antikoerper, nuclear protein transcription regulator 1 antikoerper, NUPR1 antikoerper, Nupr1 antikoerper
    Hintergrund

    Background: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 \'Lys-16\' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

    Aliases: Candidate of metastasis 1 antibody, COM1 antibody, Nuclear protein 1 antibody, Nupr1 antibody, NUPR1_HUMAN antibody, p8 protein antibody, Protein p8 antibody

    UniProt
    O60356
Sie sind hier: