NUPR1 Antikörper (AA 2-64)

Produktnummer ABIN7161848

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NUPR1 in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für NUPR1 Antikörper (AA 2-64) (ABIN7161848)

Target: NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUPR1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NUPR1 Antikörper

Bindungsspezifität: AA 2-64

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Nuclear protein 1 protein (2-64AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NUPR1

Target: NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))

Andere Bezeichnung: NUPR1

Hintergrund:

Background: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 \'Lys-16\' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Aliases: Candidate of metastasis 1 antibody, COM1 antibody, Nuclear protein 1 antibody, Nupr1 antibody, NUPR1_HUMAN antibody, p8 protein antibody, Protein p8 antibody

UniProt: O60356