Norrie Disease (Pseudoglioma) Antikörper (AA 25-133) (HRP)

Produktnummer ABIN7161712

Dieses Anti-Norrie Disease (Pseudoglioma)-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Norrie Disease (Pseudoglioma) in ELISA. Geeignet für Human.

Kurzübersicht für Norrie Disease (Pseudoglioma) Antikörper (AA 25-133) (HRP) (ABIN7161712)

Target: Norrie Disease (Pseudoglioma) (NDP)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Norrie Disease (Pseudoglioma) Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-Norrie Disease (Pseudoglioma) Antikörper (HRP)

Bindungsspezifität: AA 25-133

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Norrin protein (25-133AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Norrie Disease (Pseudoglioma)

Target: Norrie Disease (Pseudoglioma) (NDP)

Andere Bezeichnung: NDP

Hintergrund:

Background: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Aliases: EVR2 antibody, Exudative vitreoretinopathy 2 (X linked) antibody, FEVR antibody, ND antibody, NDP antibody, NDP_HUMAN antibody, Norrie disease (pseudoglioma) antibody, Norrie disease protein antibody, Norrin antibody, Norrin precursor antibody, X linked exudative vitreoretinopathy 2 protein antibody, X-linked exudative vitreoretinopathy 2 protein antibody

UniProt: Q00604

Pathways: Sensory Perception of Sound