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NPAS4 Antikörper (AA 445-585)

This anti-NPAS4 antibody (ABIN7161390) is a Rabbit Polyclonal antibody detecting NPAS4 in WB, IHC, ELISA. Suitable for Human.
Produktnummer ABIN7161390

Kurzübersicht für NPAS4 Antikörper (AA 445-585) (ABIN7161390)

Target

Alle NPAS4 Antikörper anzeigen
NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Reaktivität

  • 26
  • 21
  • 21
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 28
  • 14
  • 1
Kaninchen

Klonalität

  • 29
  • 14
Polyklonal

Konjugat

  • 22
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NPAS4 Antikörper ist unkonjugiert

Applikation

  • 28
  • 23
  • 15
  • 15
  • 14
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 10
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 445-585

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Neuronal PAS domain-containing protein 4 protein (445-585AA)

    Isotyp

    IgG
  • Applikationshinweise

    Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

    Andere Bezeichnung

    NPAS4

    Hintergrund

    Background: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).

    Aliases: bHLH PAS type transcription factor NXF antibody, bHLHe79 antibody, Class E basic helix-loop-helix protein 79 antibody, HLH-PAS transcription factor NXF antibody, Le PAS antibody, limbic enhanced PAS protein antibody, neuronal PAS domain protein 4 antibody, Neuronal PAS domain-containing protein 4 antibody, Neuronal PAS4 antibody, NPAS4 antibody, NPAS4_HUMAN antibody, NXF antibody, PAS domain-containing protein 10 antibody, PASD10 antibody

    UniProt

    Q8IUM7
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