NPAS4 Antikörper (AA 445-585)

Produktnummer ABIN7161390

Der Kaninchen Polyklonal Anti-NPAS4-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, NPAS4 in Proben von Human zu detektieren.

Kurzübersicht für NPAS4 Antikörper (AA 445-585) (ABIN7161390)

Target: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPAS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-NPAS4 Antikörper

Bindungsspezifität: AA 445-585

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Neuronal PAS domain-containing protein 4 protein (445-585AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NPAS4

Target: NPAS4 (Neuronal PAS Domain Protein 4 (NPAS4))

Andere Bezeichnung: NPAS4

Hintergrund:

Background: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).

Aliases: bHLH PAS type transcription factor NXF antibody, bHLHe79 antibody, Class E basic helix-loop-helix protein 79 antibody, HLH-PAS transcription factor NXF antibody, Le PAS antibody, limbic enhanced PAS protein antibody, neuronal PAS domain protein 4 antibody, Neuronal PAS domain-containing protein 4 antibody, Neuronal PAS4 antibody, NPAS4 antibody, NPAS4_HUMAN antibody, NXF antibody, PAS domain-containing protein 10 antibody, PASD10 antibody

UniProt: Q8IUM7