SIRT6 Antikörper (AA 1-355)

Produktnummer ABIN7160865

Der Kaninchen Polyklonal Anti-SIRT6-Antikörper wurde für ELISA validiert. Er ist geeignet, SIRT6 in Proben von Human zu detektieren.

Kurzübersicht für SIRT6 Antikörper (AA 1-355) (ABIN7160865)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT6 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-SIRT6 Antikörper

Bindungsspezifität: AA 1-355

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human NAD-dependent protein deacetylase sirtuin-6 protein (1-355AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Andere Bezeichnung: SIRT6

Hintergrund:

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

Aliases: 2810449N18Rik antibody, AI043036 antibody, Mono ADP ribosyltransferase sirtuin 6 antibody, NAD-dependent protein deacetylase sirtuin-6 antibody, Regulatory protein SIR2 homolog 6 antibody, Regulatory protein SIR2 homolog antibody, SIR2 like 6 antibody, SIR2 like protein 6 antibody, Sir2 related protein type 6 antibody, SIR2-like protein 6 antibody, SIR2L6 antibody, SIR6_HUMAN antibody, SIRT 6 antibody, SIRT6 antibody, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody, Sirtuin 6 antibody, Sirtuin type 6 antibody, Sirtuin6 antibody

UniProt: Q8N6T7