SETD8 Antikörper (AA 136-258) (Biotin)

Produktnummer ABIN7160767

Dieses Anti-SETD8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SETD8 in ELISA. Geeignet für Human.

Kurzübersicht für SETD8 Antikörper (AA 136-258) (Biotin) (ABIN7160767)

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD8 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-SETD8 Antikörper (Biotin)

Bindungsspezifität: AA 136-258

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human N-lysine methyltransferase KMT5A protein (136-258AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SETD8

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Andere Bezeichnung: KMT5A

Hintergrund:

Background: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates \\\'Lys-20\\\' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at \\\'Lys-382\\\', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Aliases: H4 K20 HMTase antibody, H4 K20 specific histone methyltransferase antibody, H4-K20-HMTase SETD8 antibody, Histone H4 K20 methyltransferase antibody, Histone lysine N methyltransferase H4 lysine 20 specific antibody, Histone-lysine N-methyltransferase SETD8 antibody, Lysine N-methyltransferase 5A antibody, N-lysine methyltransferase SETD8 antibody, Pr SET 7 antibody, Pr SET7 antibody, PR-Set7 antibody, PR/SET domain containing protein 07 antibody, PR/SET domain containing protein 8 antibody, PR/SET domain-containing protein 07 antibody, PR/SET07 antibody, PrSET7 antibody, SET 07 antibody, SET 8 antibody, SET domain containing (lysine methyltransferase) 8 antibody, SET domain containing 8 antibody, SET domain containing lysine methyltransferase 8 antibody, SET domain containing protein 8 antibody, SET domain-containing protein 8 antibody, SET07 antibody, SET8 antibody, SETD 8 antibody, setd8 antibody, SETD8_HUMAN antibody

UniProt: Q9NQR1