MFN2 Antikörper (AA 61-158)

Produktnummer ABIN7159968

Der Kaninchen Polyklonal Anti-MFN2-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, MFN2 in Proben von Human zu detektieren.

Kurzübersicht für MFN2 Antikörper (AA 61-158) (ABIN7159968)

Target: MFN2 (Mitofusin 2 (MFN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MFN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MFN2 Antikörper

Bindungsspezifität: AA 61-158

Kreuzreaktivität: Human, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mitofusin-2 protein (61-158AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:3000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Andere Bezeichnung: MFN2

Hintergrund:

Background: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

Aliases: CMT2A antibody, CMT2A2 antibody, CPRP 1 antibody, CPRP1 antibody, EC 3.6.5.- antibody, Fzo antibody, HSG antibody, hyperplasia suppressor gene antibody, Hypertension related protein 1 antibody, KIAA0214 antibody, MARF antibody, MFN 2 antibody, Mfn2 antibody, MFN2_HUMAN antibody, Mitochondrial assembly regulatory factor antibody, Mitofusin-2 antibody, Mitofusin2 antibody, Transmembrane GTPase MFN2 antibody

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development