Merlin Antikörper (AA 230-414) (FITC)

Produktnummer ABIN7159415

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Merlin in . Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Merlin Antikörper (AA 230-414) (FITC) (ABIN7159415)

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Merlin Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-Merlin Antikörper (FITC)

Bindungsspezifität: AA 230-414

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Merlin protein (230-414AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Andere Bezeichnung: NF2

Hintergrund:

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Aliases: ACN antibody, BANF antibody, Bilateral acoustic neuroma antibody, MERL_HUMAN antibody, Merlin antibody, Moesin ezrin radixin like protein antibody, Moesin ezrin radizin like antibody, Moesin-ezrin-radixin-like protein antibody, Neurofibromatosis 2 antibody, Neurofibromatosis type 2 antibody, Neurofibromatosis2 antibody, Neurofibromin 2 antibody, Neurofibromin-2 antibody, Neurofibromin2 antibody, NF 2 antibody, Nf2 antibody, SCH antibody, Schwannomerlin antibody, Schwannomin antibody

UniProt: P35240

Pathways: Cell-Cell Junction Organization