LRP4 Antikörper (AA 1500-1725)

Produktnummer ABIN7158575

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LRP4 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für LRP4 Antikörper (AA 1500-1725) (ABIN7158575)

Target: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-LRP4 Antikörper

Bindungsspezifität: AA 1500-1725

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Low-density lipoprotein receptor-related protein 4 protein (1500-1725AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LRP4

Target: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Andere Bezeichnung: LRP4

Hintergrund:

Background: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.

Aliases: KIAA0816 antibody, LDLR dan antibody, Low density lipoprotein receptor related protein 4 antibody, Low-density lipoprotein receptor-related protein 4 antibody, LRP-4 antibody, LRP10 antibody, Lrp4 antibody, LRP4_HUMAN antibody, MEGF7 antibody, Multiple epidermal growth factor like domains 7 antibody, Multiple epidermal growth factor-like domains 7 antibody

UniProt: O75096

Pathways: Skeletal Muscle Fiber Development