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LAIR1 Antikörper (AA 22-165) (HRP)

This anti-LAIR1 antibody (ABIN7158294) is a Rabbit Polyclonal antibody detecting LAIR1 in ELISA. Suitable for Human.
Produktnummer ABIN7158294

Kurzübersicht für LAIR1 Antikörper (AA 22-165) (HRP) (ABIN7158294)

Target

Alle LAIR1 Antikörper anzeigen
LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Reaktivität

  • 55
  • 22
  • 5
Human

Wirt

  • 36
  • 31
  • 2
  • 1
Kaninchen

Klonalität

  • 38
  • 32
Polyklonal

Konjugat

  • 44
  • 5
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LAIR1 Antikörper ist konjugiert mit HRP

Applikation

  • 47
  • 21
  • 21
  • 21
  • 17
  • 15
  • 1
  • 1
  • 1
ELISA
  • Bindungsspezifität

    • 7
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 22-165

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

    Andere Bezeichnung

    LAIR1

    Hintergrund

    Background: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

    Aliases: 5133400O11Rik antibody, CD305 antibody, D7Bwg0421e antibody, hLAIR1 antibody, LAIR 1 antibody, LAIR-1 antibody, LAIR1 antibody, LAIR1 protein antibody, LAIR1_HUMAN antibody, Leukocyte associated Ig like receptor 1 antibody, Leukocyte associated immunoglobulin like receptor 1 antibody, Leukocyte-associated immunoglobulin-like receptor 1 antibody

    UniProt

    Q6GTX8
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