ANKRD15 Antikörper (AA 66-255)

Produktnummer ABIN7157686

Dieses Anti-ANKRD15-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ANKRD15 in ELISA und IHC. Geeignet für Human.

Kurzübersicht für ANKRD15 Antikörper (AA 66-255) (ABIN7157686)

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANKRD15 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ANKRD15 Antikörper

Bindungsspezifität: AA 66-255

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 protein (66-255AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Andere Bezeichnung: KANK1

Hintergrund:

Background: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Aliases: ANKRD 15 antibody, Ankyrin repeat domain 15 antibody, Ankyrin repeat domain containing protein 15 antibody, Ankyrin repeat domain-containing protein 15 antibody, DKFZp451G231 antibody, KANK antibody, KANK1 antibody, KANK1_HUMAN antibody, KIAA0172 antibody, Kidney ankyrin repeat containing protein antibody, Kidney ankyrin repeat-containing protein antibody, KN motif and ankyrin repeat domain-containing protein 1 antibody, MGC43128 antibody

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization