KLHL22 Antikörper (AA 2-300)

Produktnummer ABIN7157281

Produktdetails anti-KLHL22 Antikörper

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Bindungsspezifität: AA 2-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLHL22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Kelch-like protein 22 protein (2-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KLHL22

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Andere Bezeichnung: KLHL22 (KLHL22 Produkte)

Synonyme: 2610318I18Rik antikoerper, Kelchl antikoerper, KELCHL antikoerper, RGD1306288 antikoerper, kelch-like 22 antikoerper, kelch like family member 22 antikoerper, kelch-like family member 22 antikoerper, Klhl22 antikoerper, KLHL22 antikoerper

Hintergrund:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Aliases: KLHL22Kelch-like protein 22 antibody

UniProt: Q53GT1