KLHL2 Antikörper (AA 1-200) (FITC)

Produktnummer ABIN7157279

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KLHL2 in . Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für KLHL2 Antikörper (AA 1-200) (FITC) (ABIN7157279)

Target: KLHL2 (Kelch-Like 2, Mayven (KLHL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLHL2 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Produktdetails anti-KLHL2 Antikörper (FITC)

Bindungsspezifität: AA 1-200

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Kelch-like protein 20 protein (1-200AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KLHL2

Target: KLHL2 (Kelch-Like 2, Mayven (KLHL2))

Andere Bezeichnung: KLHL2

Hintergrund:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates \'Lys-33\'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating \'Lys-33\'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).

Aliases: Kelch like ECT2 interacting protein antibody, Kelch like protein 20 antibody, Kelch like protein X antibody, Kelch motif containing protein antibody, Kelch-like ECT2-interacting protein antibody, Kelch-like protein 20 antibody, Kelch-like protein X antibody, KHLHX antibody, KLEIP antibody, KLH20_HUMAN antibody, KLHL20 antibody, KLHLX antibody, RP3-383J4.3 antibody

UniProt: Q9Y2M5