Integrin beta 3 Antikörper (AA 609-788)

Produktnummer ABIN7156485

Produktdetails anti-Integrin beta 3 Antikörper

Target: Integrin beta 3 (ITGB3)

Bindungsspezifität: AA 609-788

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Integrin beta-3 protein (609-788AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: ITGB3 (ITGB3 Produkte)

Synonyme: BDPLT16 antikoerper, BDPLT2 antikoerper, CD61 antikoerper, GP3A antikoerper, GPIIIa antikoerper, GT antikoerper, INGRB3 antikoerper, integrin antikoerper, INTB3 antikoerper, GPIIIA antikoerper, cd61 antikoerper, gp3a antikoerper, itgb3 antikoerper, itgb3.2 antikoerper, itgb3.1 antikoerper, integrin subunit beta 3 antikoerper, integrin beta 3 antikoerper, integrin subunit beta 3 L homeolog antikoerper, integrin beta 3a antikoerper, integrin beta 3b antikoerper, ITGB3 antikoerper, Itgb3 antikoerper, itgb3.L antikoerper, itgb3a antikoerper, itgb3b antikoerper

Hintergrund:

Background: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\\\'s sarcoma lesions.

Aliases: BDPLT16 antibody, BDPLT2 antibody, CD 61 antibody, CD61 antibody, CD61 antigen antibody, GP3A antibody, GPIIIa antibody, GT antibody, HPA 1 antibody, HPA 4 antibody, Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody, Integrin beta chain beta 3 antibody, Integrin beta-3 antibody, ITB3_HUMAN antibody, ITG B3 antibody, ITGB 3 antibody, ITGB3 antibody, NAIT antibody, platelet fibrinogen receptor antibody, Platelet fibrinogen receptor beta subunit antibody, Platelet fibrinogen receptor, beta subunit antibody, Platelet glycoprotein IIIa antibody, Platelet glycoprotein IIIa precursor antibody, Platelet membrane glycoprotein IIIa antibody, PTP antibody

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex