KPNA6 Antikörper (AA 277-536)

Produktnummer ABIN7156132

Dieses Anti-KPNA6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KPNA6 in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für KPNA6 Antikörper (AA 277-536) (ABIN7156132)

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-KPNA6 Antikörper

Bindungsspezifität: AA 277-536

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Importin subunit alpha-7 protein (277-536AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KPNA6

Target: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Andere Bezeichnung: KPNA6

Hintergrund:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Aliases: FLJ11249 antibody, IMA7_HUMAN antibody, Importin alpha 7 subunit antibody, Importin alpha S2 antibody, Importin subunit alpha 7 antibody, Importin subunit alpha-7 antibody, IPOA 7 antibody, IPOA7 antibody, Karyopherin alpha 6 antibody, Karyopherin alpha 6 (importin alpha 7) antibody, Karyopherin subunit alpha 6 antibody, Karyopherin subunit alpha-6 antibody, KPNA 6 antibody, KPNA 7 antibody, Kpna6 antibody, KPNA7 antibody, MGC17918 antibody, OTTHUMP00000004532 antibody

UniProt: O60684

Pathways: Protein targeting to Nucleus