KPNA5 Antikörper (AA 1-240)

Produktnummer ABIN7156130

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KPNA5 in WB, ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für KPNA5 Antikörper (AA 1-240) (ABIN7156130)

Target: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-KPNA5 Antikörper

Bindungsspezifität: AA 1-240

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Importin subunit alpha-6 protein (1-240AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KPNA5

Target: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Andere Bezeichnung: KPNA5

Hintergrund:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Aliases: IMA5_HUMAN antibody, Importin alpha 6 antibody, Importin subunit alpha 6 antibody, Importin subunit alpha-6 antibody, IPOA 6 antibody, IPOA6 antibody, Karyopherin alpha 5 antibody, Karyopherin alpha 5 importin alpha 6 antibody, Karyopherin subunit alpha 5 antibody, Karyopherin subunit alpha-5 antibody, KPNA 5 antibody, KPNA5 antibody, SRP 6 antibody, SRP6 antibody

UniProt: O15131

Pathways: Protein targeting to Nucleus