Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) Antikörper (HRP)

Produktnummer ABIN7156076

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Human Immunodeficiency Virus Vpx in ELISA. Er zeigt eine Reaktivität gegenüber Human Immunodeficiency Virus (HIV).

Kurzübersicht für Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) Antikörper (HRP) (ABIN7156076)

Target: Human Immunodeficiency Virus Vpx (HIV Vpx)

Reaktivität: Human Immunodeficiency Virus (HIV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: HRP

Applikation: ELISA

Produktdetails

Bindungsspezifität: AA 1-112

Verwendungszweck: vpx Antibody, HRP conjugated

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: Human Immunodeficiency Virus Vpx (HIV Vpx)

Andere Bezeichnung: HIV vpx

Substanzklasse: Viral Protein

Hintergrund:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).

Aliases: vpxProtein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P06939