HIPK3 Antikörper (AA 841-1130)

Produktnummer ABIN7155869

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HIPK3 in ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HIPK3 Antikörper (AA 841-1130) (ABIN7155869)

Target: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIPK3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-HIPK3 Antikörper

Bindungsspezifität: AA 841-1130

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Homeodomain-interacting protein kinase 3 protein (841-1130AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HIPK3

Target: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Andere Bezeichnung: HIPK3

Hintergrund:

Background: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Aliases: Androgen receptor interacting nuclear protein kinase antibody, Androgen receptor-interacting nuclear protein kinase antibody, ANPK antibody, DYRK6 antibody, Fas interacting serine/threonine protein kinase antibody, Fas-interacting serine/threonine-protein kinase antibody, FIST antibody, FIST3 antibody, Hipk3 antibody, HIPK3_HUMAN antibody, homeodomain interacting protein kinase 3 antibody, Homeodomain-interacting protein kinase 3 antibody, Homolog of protein kinase YAK1 antibody, PKY antibody, RP24 297H17.5 antibody, YAK1 antibody

UniProt: Q9H422