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EZH2 Antikörper (AA 1-250)

EZH2 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7155480
  • Target Alle EZH2 Antikörper anzeigen
    EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
    Bindungsspezifität
    • 16
    • 15
    • 8
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-250
    Reaktivität
    • 112
    • 44
    • 13
    • 9
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 90
    • 23
    • 1
    Kaninchen
    Klonalität
    • 76
    • 38
    Polyklonal
    Konjugat
    • 70
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EZH2 Antikörper ist unkonjugiert
    Applikation
    • 71
    • 40
    • 39
    • 27
    • 25
    • 21
    • 15
    • 13
    • 12
    • 12
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Histone-lysine N-methyltransferase EZH2 protein (1-250AA)
    Isotyp
    IgG
    Top Product
    Discover our top product EZH2 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
    Andere Bezeichnung
    EZH2 (EZH2 Produkte)
    Hintergrund

    Background: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates \\\'Lys-9\\\' (H3K9me) and \\\'Lys-27\\\' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate \\\'Lys-27\\\' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer, involved in the di and trimethylation of \\\'Lys-27\\\' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.

    Aliases: Enhancer of zeste 2 antibody, enhancer of zeste 2 polycomb repressive complex 2 subunit antibody, Enhancer of zeste homolog 2 (Drosophila) antibody, Enhancer of zeste homolog 2 antibody, Enhancer of zeste, Drosophila, homolog 2 antibody, ENX 1 antibody, Enx 1h antibody, ENX-1 antibody, ENX1 antibody, Enx1h antibody, EZH 2 antibody, EZH1 antibody, EZH2 antibody, EZH2_HUMAN antibody, EZH2b antibody, Histone-lysine N-methyltransferase EZH2 antibody, KMT 6 antibody, KMT6 antibody, KMT6A antibody, Lysine N-methyltransferase 6 antibody, MGC9169 antibody, WVS antibody, WVS2 antibody

    UniProt
    Q15910
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
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