Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

HRG Antikörper (AA 412-511) (Biotin)

Dieses Anti-HRG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HRG in ELISA. Geeignet für Human.
Produktnummer ABIN7155259

Kurzübersicht für HRG Antikörper (AA 412-511) (Biotin) (ABIN7155259)

Target

Alle HRG Antikörper anzeigen
HRG (Histidine-Rich Glycoprotein (HRG))

Reaktivität

  • 44
  • 22
  • 13
  • 2
Human

Wirt

  • 45
  • 31
  • 1
Kaninchen

Klonalität

  • 45
  • 32
Polyklonal

Konjugat

  • 58
  • 8
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HRG Antikörper ist konjugiert mit Biotin

Applikation

  • 66
  • 51
  • 37
  • 34
  • 8
  • 4
  • 4
  • 2
  • 2
  • 2
ELISA
  • Bindungsspezifität

    • 15
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 412-511

    Kreuzreaktivität

    Human

    Aufreinigung

    >95%, Protein G purified

    Immunogen

    Recombinant Human Histidine-rich glycoprotein protein (412-511AA)

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    HRG (Histidine-Rich Glycoprotein (HRG))

    Andere Bezeichnung

    HRG

    Hintergrund

    Background: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway, inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis.

    Aliases: HRG antibody, Histidine-rich glycoprotein antibody, Histidine-proline-rich glycoprotein antibody, HPRG antibody

    UniProt

    P04196
Sie sind hier:
Chat with us!