PDE9A Antikörper (AA 426-533)

Produktnummer ABIN7155179

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PDE9A in ELISA, WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PDE9A Antikörper (AA 426-533) (ABIN7155179)

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE9A Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PDE9A Antikörper

Bindungsspezifität: AA 426-533

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human High affinity cGMP-specific 3\\\',5\\\'-cyclic phosphodiesterase 9A protein (426-533AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PDE9A

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Andere Bezeichnung: PDE9A

Hintergrund:

Background: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).

Aliases: 5''-cyclic phosphodiesterase 9A antibody, cGMP specific 3' 5' cyclic phosphodiesterase type 9 antibody, FLJ90181 antibody, High affinity cGMP-specific 3'' antibody, High-affinity cGMP-specific 3'5'-cyclic phosphodiesterase 9A antibody, HSPDE9A2 antibody, OTTHUMP00000109399 antibody, PDE 9A antibody, Pde9a antibody, PDE9A_HUMAN antibody, Phosphodiesterase 9A antibody, phosphodiesterase PDE9A21 antibody

UniProt: O76083