GNA12 Antikörper (AA 112-270)

Produktnummer ABIN7154731

Dieses Anti-GNA12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GNA12 in WB, ELISA, IHC und IF. Geeignet für Human.

Kurzübersicht für GNA12 Antikörper (AA 112-270) (ABIN7154731)

Target: GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNA12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-GNA12 Antikörper

Bindungsspezifität: AA 112-270

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GNA12

Target: GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))

Andere Bezeichnung: GNA12

Hintergrund:

Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

Aliases: G alpha 12 antibody, G alpha-12 antibody, G-protein subunit alpha-12 antibody, gep antibody, Gna12 antibody, GNA12_HUMAN antibody, guanine nucleotide binding protein (G protein) alpha 12 antibody, Guanine nucleotide binding protein alpha 12 subunit antibody, Guanine nucleotide-binding protein subunit alpha-12 antibody, MGC104623 antibody, MGC99644 antibody, NNX3 antibody, RMP antibody, WUGSC:H_GS165O14.2 antibody

UniProt: Q03113