GRHL3 Antikörper (AA 31-182)

Produktnummer ABIN7154380

Dieses Anti-GRHL3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRHL3 in ELISA und IF. Geeignet für Human.

Kurzübersicht für GRHL3 Antikörper (AA 31-182) (ABIN7154380)

Target: GRHL3 (Grainyhead-Like 3 (GRHL3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRHL3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-GRHL3 Antikörper

Bindungsspezifität: AA 31-182

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Grainyhead-like protein 3 homolog protein (31-182AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GRHL3

Target: GRHL3 (Grainyhead-Like 3 (GRHL3))

Andere Bezeichnung: GRHL3

Hintergrund:

Background: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).

Aliases: Drosophila antibody, Grainyhead like 3 antibody, Grainyhead like protein 3 homolog antibody, Grainyhead-like protein 3 homolog antibody, grhl3 antibody, GRHL3_HUMAN antibody, Sister of mammalian grainyhead antibody, Sister of mammalian grainyhead protein antibody, SOM antibody, TFCP2L4 antibody, Transcription factor CP2 like 4 antibody, Transcription factor CP2-like 4 antibody

UniProt: Q8TE85