Glutaredoxin 2 Antikörper (AA 1-124)

Produktnummer ABIN7154050

Dieses Anti-Glutaredoxin 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Glutaredoxin 2 in ELISA und IHC. Geeignet für Human.

Kurzübersicht für Glutaredoxin 2 Antikörper (AA 1-124) (ABIN7154050)

Target: Glutaredoxin 2 (GRX2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutaredoxin 2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Glutaredoxin 2 Antikörper

Bindungsspezifität: AA 1-124

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Glutaredoxin-2, mitochondrial protein (1-124AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Andere Bezeichnung: GLRX2

Hintergrund:

Background: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Aliases: bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody, bA101E13.1 antibody, CGI133 antibody, Glrx2 antibody, GLRX2_HUMAN antibody, Glutaredoxin-2 antibody, Glutaredoxin-2, mitochondrial antibody, GRX2 antibody, mitochondrial antibody

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis