Gasdermin A Antikörper (AA 64-172) (FITC)
Kurzübersicht für Gasdermin A Antikörper (AA 64-172) (FITC) (ABIN7153649)
Target
Alle Gasdermin A (GSDMA) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 64-172
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Kreuzreaktivität
- Human
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Aufreinigung
- >95%, Protein G purified
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Immunogen
- Recombinant Human Gasdermin-A protein (64-172AA)
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Isotyp
- IgG
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Gasdermin A (GSDMA)
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Andere Bezeichnung
- GSDMA
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Hintergrund
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Background: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
Aliases: GSDMA antibody, GSDM antibody, GSDM1 antibody, FKSG9Gasdermin-A antibody, Gasdermin-1 antibody
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UniProt
- Q96QA5
Target
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