GPR161 Antikörper (AA 1-28) (HRP)

Produktnummer ABIN7153330

Dieses Anti-GPR161-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GPR161 in ELISA. Geeignet für Human.

Kurzübersicht für GPR161 Antikörper (AA 1-28) (HRP) (ABIN7153330)

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR161 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-GPR161 Antikörper (HRP)

Bindungsspezifität: AA 1-28

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human G-protein coupled receptor 161 protein (1-28AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GPR161

Target: GPR161 (G Protein-Coupled Receptor 161 (GPR161))

Andere Bezeichnung: GPR161

Hintergrund:

Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Aliases: GPR161 antibody, G-protein coupled receptor 161 antibody, G-protein coupled receptor RE2 antibody

UniProt: Q8N6U8

Pathways: cAMP Metabolic Process