FOXN1 Antikörper (AA 1-160) (Biotin)

Produktnummer ABIN7153071

Der Kaninchen Polyklonal Anti-FOXN1-Antikörper wurde für ELISA validiert. Er ist geeignet, FOXN1 in Proben von Human zu detektieren.

Kurzübersicht für FOXN1 Antikörper (AA 1-160) (Biotin) (ABIN7153071)

Target: FOXN1 (Forkhead Box N1 (FOXN1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXN1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-FOXN1 Antikörper (Biotin)

Bindungsspezifität: AA 1-160

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Forkhead box protein N1 protein (1-160AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FOXN1

Target: FOXN1 (Forkhead Box N1 (FOXN1))

Andere Bezeichnung: FOXN1

Hintergrund:

Background: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).

Aliases: FKHL20 antibody, Forkhead box N1 antibody, Forkhead box protein N1 antibody, FOXN 1 antibody, FOXN1 antibody, FOXN1_HUMAN antibody, RONU antibody, Rowett nude antibody, Transcription factor winged-helix nude antibody, WHN antibody, Winged helix nude antibody, Winged-helix transcription factor nude antibody

UniProt: O15353