FERMT2 Antikörper (AA 155-232) (Biotin)

Produktnummer ABIN7152703

Dieses Anti-FERMT2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FERMT2 in ELISA. Geeignet für Human.

Kurzübersicht für FERMT2 Antikörper (AA 155-232) (Biotin) (ABIN7152703)

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FERMT2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-FERMT2 Antikörper (Biotin)

Bindungsspezifität: AA 155-232

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Fermitin family homolog 2 protein (155-232AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Andere Bezeichnung: FERMT2

Hintergrund:

Background: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Aliases: FLJ34213 antibody, FLJ44462 antibody, UNC112 antibody, FERM2_HUMAN antibody, Fermitin family homolog 2 antibody, Fermt2 antibody, KIND2 antibody, Kindlin-2 antibody, MIG-2 antibody, MIG2 antibody, Mitogen-inducible gene 2 protein antibody, PH domain-containing family C member 1 antibody, Pleckstrin homology domain containing family C (with FERM domain) member 1 antibody, Pleckstrin homology domain-containing family C member 1 antibody, PLEKHC1 antibody, UNC112B antibody

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization