FBXW11 Antikörper (AA 1-140)

Produktnummer ABIN7152490

Dieses Anti-FBXW11-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FBXW11 in ELISA und IHC. Geeignet für Human.

Kurzübersicht für FBXW11 Antikörper (AA 1-140) (ABIN7152490)

Target: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW11 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FBXW11 Antikörper

Bindungsspezifität: AA 1-140

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human F-box/WD repeat-containing protein 11 protein (1-140AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FBXW11

Target: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Andere Bezeichnung: FBXW11

Hintergrund:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Aliases: beta Transducin Repeat Containing Protein 2 antibody, BTRC2 antibody, BTRCP2 antibody, F-box and WD repeats protein beta-TrCP2 antibody, F-box and WD-40 Domain Protein 1B antibody, F-box Protein FBW1B antibody, F-box/WD repeat-containing protein 11 antibody, F-box/WD repeat-containing protein 1B antibody, FBW1B antibody, FBW1B_HUMAN antibody, FBXW11 antibody, FBXW1B antibody, Homologous to Slimb protein antibody, HOS antibody

UniProt: Q9UKB1