FBXL2 Antikörper (AA 1-423)

Produktnummer ABIN7152472

Dieses Anti-FBXL2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FBXL2 in ELISA und IF. Geeignet für Human.

Kurzübersicht für FBXL2 Antikörper (AA 1-423) (ABIN7152472)

Target: FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXL2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Produktdetails anti-FBXL2 Antikörper

Bindungsspezifität: AA 1-423

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FBXL2

Target: FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))

Andere Bezeichnung: FBXL2

Hintergrund:

Background: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Aliases: DKFZP564P0622 antibody, F box and leucine rich repeat protein 2 antibody, F box protein containing leucine rich repeats antibody, F box protein FBL2/FBL3 antibody, F box/LRR repeat protein 2 antibody, F-box and leucine-rich repeat protein 2 antibody, F-box protein FBL2/FBL3 antibody, F-box/LRR-repeat protein 2 antibody, FBL 2 antibody, FBL 3 antibody, FBL2 antibody, FBL3 antibody, FBXL 2 antibody, FBXL2 antibody, FBXL2_HUMAN antibody

UniProt: Q9UKC9