FBXO9 Antikörper (AA 13-111) (Biotin)

Produktnummer ABIN7152452

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FBXO9 in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FBXO9 Antikörper (AA 13-111) (Biotin) (ABIN7152452)

Target: FBXO9 (F-Box Protein 9 (FBXO9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO9 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-FBXO9 Antikörper (Biotin)

Bindungsspezifität: AA 13-111

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human F-box only protein 9 protein (13-111AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FBXO9

Target: FBXO9 (F-Box Protein 9 (FBXO9))

Andere Bezeichnung: FBXO9

Hintergrund:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Aliases: Cross-immune reaction antigen 1 antibody, dJ341E18.2 antibody, DKFZp434C0118 antibody, F-box only protein 9 antibody, Fbp24 antibody, FBX09 antibody, FBX9 antibody, FBX9_HUMAN antibody, Fbxo9 antibody, KIAA0936 antibody, NY REN 57 antibody, OTTHUMP00000016628 antibody, OTTHUMP00000016629 antibody, OTTHUMP00000214588 antibody, Renal carcinoma antigen NY-REN-57 antibody, VCIA1 antibody

UniProt: Q9UK97