EYA2 Antikörper (AA 1-514)

Produktnummer ABIN7152359

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EYA2 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für EYA2 Antikörper (AA 1-514) (ABIN7152359)

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-EYA2 Antikörper

Bindungsspezifität: AA 1-514

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Eyes absent homolog 2 protein (1-514AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EYA2

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Andere Bezeichnung: EYA2

Hintergrund:

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates \'Tyr-142\' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. \'Tyr-142\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1.

Aliases: EAB 1 antibody, EAB1 antibody, EYA 2 antibody, EYA transcriptional coactivator and phosphatase 2 antibody, EYA2 antibody, EYA2_HUMAN antibody, eyes absent 2 homolog (Drosophila) antibody, Eyes absent homolog 2 (Drosophila) antibody, Eyes absent homolog 2 antibody, Translation of this uORF probably lowers the translation efficiency of EYA2 antibody

UniProt: O00167