EYA1 Antikörper (AA 168-321) (HRP)

Produktnummer ABIN7152358

Dieses Anti-EYA1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EYA1 in ELISA. Geeignet für Human.

Kurzübersicht für EYA1 Antikörper (AA 168-321) (HRP) (ABIN7152358)

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-EYA1 Antikörper (HRP)

Bindungsspezifität: AA 168-321

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Eyes absent homolog 1 protein (168-321AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EYA1

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Andere Bezeichnung: EYA1

Hintergrund:

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates \'Tyr-142\' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. \'Tyr-142\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2 (By similarity).

Aliases: BOP antibody, BOR antibody, BOS1 antibody, EYA transcriptional coactivator and phosphatase 1 antibody, Eya1 antibody, EYA1_HUMAN antibody, Eyes absent 1 antibody, Eyes absent 1 homolog antibody, Eyes absent homolog 1 (Drosophila) antibody, Eyes absent homolog 1 antibody, Eyes absent homolog1 antibody, MGC141875 antibody, OFC1 antibody

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus