EIF4A3 Antikörper (AA 6-166) (HRP)

Produktnummer ABIN7152117

Der Kaninchen Polyklonal Anti-EIF4A3-Antikörper wurde für ELISA validiert. Er ist geeignet, EIF4A3 in Proben von Human zu detektieren.

Kurzübersicht für EIF4A3 Antikörper (AA 6-166) (HRP) (ABIN7152117)

Target: EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF4A3 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Produktdetails anti-EIF4A3 Antikörper (HRP)

Bindungsspezifität: AA 6-166

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Eukaryotic initiation factor 4A-III protein (6-166AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EIF4A3

Target: EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))

Andere Bezeichnung: EIF4A3

Hintergrund:

Background: ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly. Involved in craniofacial development.

Aliases: ATP-dependent RNA helicase DDX48 antibody, ATP-dependent RNA helicase eIF4A-3 antibody, DDX48 antibody, DEAD box protein 48 antibody, eIF-4A-III antibody, eIF4A-III antibody, EIF4A3 antibody, eIF4AIII antibody, Eukaryotic initiation factor 4A-III antibody, Eukaryotic initiation factor 4A-like NUK-34 antibody, Eukaryotic translation initiation factor 4A isoform 3 antibody, hNMP 265 antibody, IF4A3_HUMAN antibody, NMP 265 antibody, NMP265 antibody, Nuclear matrix protein 265 antibody, NUK34 antibody

UniProt: P38919