RNF128 Antikörper (AA 229-400)

Produktnummer ABIN7151138

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RNF128 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RNF128 Antikörper (AA 229-400) (ABIN7151138)

Target: RNF128 (Ring Finger Protein 128 (RNF128))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF128 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-RNF128 Antikörper

Bindungsspezifität: AA 229-400

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF128

Target: RNF128 (Ring Finger Protein 128 (RNF128))

Andere Bezeichnung: RNF128

Hintergrund:

Background: E3 ubiquitin-protein ligase that catalyzes \\\'Lys-48\\\'- and \\\'Lys-63\\\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \\\'Lys-48\\\' linkages and COR1A with \\\'Lys-63\\\' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm, sensitizes ectoderm to respond to neural-inducing signals.

Aliases: E3 ubiquitin protein ligase RNF128 antibody, E3 ubiquitin-protein ligase RNF128 antibody, FLJ23516 antibody, Gene related to anergy in lymphocytes protein antibody, GRAIL antibody, RING finger protein 128 antibody, RN128_HUMAN antibody, RNF128 antibody

UniProt: Q8TEB7