RNF41 Antikörper (AA 1-317)

Produktnummer ABIN7151092

Dieses Anti-RNF41-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RNF41 in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für RNF41 Antikörper (AA 1-317) (ABIN7151092)

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF41 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RNF41 Antikörper

Bindungsspezifität: AA 1-317

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF41

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Andere Bezeichnung: RNF41

Hintergrund:

Background: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Aliases: 4930511A05Rik antibody, 4933415P08Rik antibody, E3 ubiquitin protein ligase NRDP1 antibody, E3 ubiquitin-protein ligase NRDP1 antibody, Fetal Liver RING finger protein antibody, FLRF antibody, MGC45228 antibody, Neuregulin receptor degradation protein 1 antibody, NRDP1 antibody, RING finger protein 41 antibody, rnf41 antibody, RNF41_HUMAN antibody, SBBI03 antibody

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interaktom