NHLRC1 Antikörper (AA 86-395) (Biotin)

Produktnummer ABIN7151089

Produktdetails anti-NHLRC1 Antikörper (Biotin)

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Bindungsspezifität: AA 86-395

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NHLRC1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NHLRC1

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Andere Bezeichnung: NHLRC1 (NHLRC1 Produkte)

Synonyme: EPM2A antikoerper, EPM2B antikoerper, MALIN antikoerper, bA204B7.2 antikoerper, AI505271 antikoerper, B230309E09Rik antikoerper, Epm2b antikoerper, malin-like antikoerper, NHL repeat containing E3 ubiquitin protein ligase 1 antikoerper, NHL repeat containing 1 antikoerper, NHLRC1 antikoerper, Nhlrc1 antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Aliases: E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B

UniProt: Q6VVB1